Manuel I. Capel Tunon and Laura K. Dillon and Theresa M. Casey and Betty H. C. Cheng
February, 2009
This technical report documents a preliminary case study in which hybrid automata were used to model dynamics of fat metabolism in rat dams during pregnancy. The model describes effects of lipoprotein lipase (LPL) and hormone sensitive lipase (HSL) enzyme activities in the mammary gland and adipose tissue on blood triglyceride concentration during pregnancy in rat dams. In future work, we will refine the model and tune it to fit with data collected from animal experiments. We will then assess the model's predictive ability. We will also investigate how the model can be used to validate the experimental data.
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